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Record Details

Record 25 of 50588
Body Weight Gain during Altered Gravity: Spaceflight, Centrifugation and Transitions
Author and Affiliation:
Wade, Charles E.(NASA Ames Research Center, Moffett Field, CA United States)
Harper, J. S.(NASA Ames Research Center, Moffett Field, CA United States)
Daunton, N. G.(NASA Ames Research Center, Moffett Field, CA United States)
Corcoran, M. L.(NASA Ames Research Center, Moffett Field, CA United States)
Morey-Holton, E.(NASA Ames Research Center, Moffett Field, CA United States)
Hargens, Alan R. [Technical Monitor]
Abstract: Gravity is a force that influences all living systems, and is often disregarded in the study of environment on growth and development. To assess the effect of gravity exposure on growth, immature rats (130-200 g) were evaluated during chronic altered gravity exposure and during transition between gravity fields. The effects of 14 days of spaceflight on body weight gain were evaluated (n=12) and compared to controls. Spaceflight did not affect weight gain. In 6 rats, the transition from spaceflight to 1 G showed a significant (p less than 0.05) post flight weight loss over 48 hr of 13 g compared to controls. Over subsequent days this loss was compensated for with no difference noted after 5 days. Exposure to hypergravity, 2 G for 16 days, was evaluated in groups of n=6 (Control; On Center Control (OCC); Centrifuged). With centrifugation or OCC there was a reduction in body weight within 24 hr. The OCC regained control weights within 13 days. The weight difference, 26 +/- 1 g, persisted with 2 G with no subsequent difference in weight gain over days 3-16 compared to controls; 3.7 +/- 0.1 versus 3.9 +/- 0.1 g/day respectively. Transition from centrifugation to 1 G resulted in a weight increase within 48 hours. Over 16 days the rate of gain was increased 3.1 +/- 0.1 g/day for centrifuge compared to 2.1 +/- 0.1 g/day for controls between Day 3 to 16. However, differences from control were still noted on Day 16. Transition from one gravity field to another causes acute changes in body weight. Transition to microgravity or 1 G, following the acute changes, results in adjustments to attain a normal weight. In hypergravity the acute reduction in body weight persist, but weight gain is normal. Transitioning from hypergravity to 1G results in an increased weight gain to compensate for the persistent reduction during exposure.
Publication Date: Jan 01, 1995
Document ID:
20020017035
(Acquired Feb 08, 2002)
Subject Category: AEROSPACE MEDICINE
Document Type: Preprint
Meeting Information: 16th Annual Gravitational Physiology Meeting; 19-24 Mar. 1995; Reno, NV; United States
Contract/Grant/Task Num: RTOP 199-16-12-01
Financial Sponsor: NASA Ames Research Center; Moffett Field, CA United States
Organization Source: NASA Ames Research Center; Moffett Field, CA United States
Description: 1p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: No Copyright
NASA Terms: MICROGRAVITY; LOSSES; GRAVITATIONAL EFFECTS; CENTRIFUGING; BODY WEIGHT; SPACE FLIGHT; RATS; HIGH GRAVITY ENVIRONMENTS; GRAVITATIONAL FIELDS; EXPOSURE
Availability Source: Other Sources
Availability Notes: Abstract Only
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