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Cancer Risk-Assessment of Radiation Damage in Ataxia-Telangiectasia Heterozygous Human Breast Epithelial Cell CulturesThis paper describes the study of the markers of cellular changes that are found during the onset of carcinogenesis. Several of the biological factors are markers of stress response, oncoprotein expression, and differentiation factors. Oxidative stress response agents such as heat shock proteins (HSPs) protect cells from oxidative stresses such as ionizing radiation. The onocoprotein HER-2/neu, a specific breast cancer marker, indicates early onset of cancer. Additional structural and morphogenetic markers of differentiation were considered in order to determine initial cellular changes at the initial onset of cancer. As an additional consideration, all-trans retinoic acid (RA), a differentiation agent, was considered because of its known role in regulating normal differentiation and inhibiting tumor proliferation via specific nuclear receptors. This paper discusses study and results of the preliminary analyses of gamma irradiation of AT heterozygous human breast epithelial cells (WH). Comparisons are also made of the effects various RA concentrations post-irradiation.
Document ID
20020068795
Acquisition Source
Marshall Space Flight Center
Document Type
Contribution to a larger work
Authors
Lisa C. Applewhite
(Spelman College Atlanta, Georgia, United States)
Date Acquired
August 20, 2013
Publication Date
July 1, 2002
Publication Information
Publication: Research Reports-2001 NASA/ASEE Summer Faculty Fellowship Program
Publisher: Marshall Space Flight Center
Volume: NASA/CR-2002-211840
Issue Publication Date: July 1, 2002
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NAG8-1786
Distribution Limits
Public
Copyright
Public Use Permitted.
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