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Record 60 of 1007
Core Research Program, Year 5
Availability: Available in document 20020087588 , or for help Contact the Information Desk
Abstract: Dramatic losses of bone mineral density (BMD) and muscle strength are two of the best documented changes observed in humans after prolonged exposure to microgravity. Recovery of muscle upon return to a 1-G environment is well studied, however, far less is known about the rate and completeness of BMD recovery to pre-flight values. Using the mature tail-suspended adult rat model, this proposal will focus on the temporal course of recovery in tibial bone following a 28-d period of skeletal unloading. Through the study of bone density and muscle strength in the same animal, time-points during recovery from simulated microgravity will be identified when bone is at an elevated risk for fracture. These will occur due to the rapid recovery of muscle strength coupled with a slower recovery of bone, producing a significant mismatch in functional strength of these two tissues. Once the time-point of maximal mismatch is defined, various mechanical and pharmacological interventions will be tested at and around this time-point in attempt to minimize the functional difference of bone and muscle. The outcomes of this research will have high relevance for optimizing the rehabilitation of astronauts upon return to Earth, as well as upon landing on the Martian surface before assuming arduous physical tasks. Further. it will impact significantly on rehabilitation issues common to patients experiencing long periods of limb immobilization or bed rest.
Publication Date: Sep 30, 2002
Document ID:
20020087591
(Acquired Nov 29, 2002)
Subject Category: AEROSPACE MEDICINE
Coverage: FY 2002
Document Type: Technical Report
Publication Information: SEE parent document record, "National Space Biomedical Research Institute"
Contract/Grant/Task Num: NCC9-58
Financial Sponsor: NASA Johnson Space Center; Houston, TX United States
Organization Source: National Space Biomedical Research Inst.; Houston, TX United States
Description: 629p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: No Copyright
NASA Terms: MUSCULOSKELETAL SYSTEM; RESEARCH AND DEVELOPMENT; NASA PROGRAMS; MICROGRAVITY; BONE MINERAL CONTENT; AEROSPACE MEDICINE; MARS SURFACE; TIBIA; CARDIOVASCULAR SYSTEM; MUSCULAR STRENGTH; HINDLIMB SUSPENSION; RATS; TISSUES (BIOLOGY)
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