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Science Issues Associated with the Use of a Microfluidic Chip Designed Specifically for Protein CrystallizationThe Iterative Biological Crystallization team in partnership with Caliper Technologies has produced a prototype microfluidic chip for batch crystallization that has been designed and tested. The chip is designed for the mixing and dispensing of up to five solutions with possible variation of the recipe being delivered to two growth wells. Developments that have led to the successful on-chip crystallization of a few model proteins have required investigative insight into many different areas, including fluid mixing dynamics, surface treatments, quantification and fidelity of reagent delivery. This presentation will encompass the ongoing studies and data accumulated toward these efforts.
Document ID
20030065930
Document Type
Preprint (Draft being sent to journal)
Authors
Holmes, Anna M. (Alabama Univ. Huntsville, AL, United States)
Monaco, Lisa (Morgan Research Corp. Huntsville, AL, United States)
Barnes, Cindy (Universities Space Research Association Huntsville, AL, United States)
Spearing, Scott (Morgan Research Corp. Huntsville, AL, United States)
Jenkins, Andy (Morgan Research Corp. Huntsville, AL, United States)
Johnson, Todd (Micro Craft, Inc. Huntsville, AL, United States)
Mayer, Derek (AI Signal Research, Inc. Huntsville, AL, United States)
Cole, Helen (NASA Marshall Space Flight Center Huntsville, AL, United States)
Date Acquired
August 21, 2013
Publication Date
January 1, 2003
Subject Category
Solid-State Physics
Meeting Information
American Crystallographic Association (ACA)(Covington, KY)
Funding Number(s)
CONTRACT_GRANT: NCC8-66
Distribution Limits
Public
Copyright
Other