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Chemical Amplification with Encapsulated ReagentsAutocatalysis and chemical amplification are characteristic properties of living systems, and they give rise to behaviors such as increased sensitivity, responsiveness, and self-replication. Here we report a synthetic system in which a unique form of compartmentalization leads to nonlinear, autocatalytic behavior. The compartment is a reversibly formed capsule in which a reagent is sequestered. Reaction products displace the reagent from the capsule into solution and the reaction rate is accelerated. The resulting self-regulation is sensitive to the highly selective molecular recognition properties of the capsule.
Document ID
20030067886
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Chen, Jian
(Scripps Institution of Oceanography La Jolla, CA, United States)
Koemer, Steffi
(Scripps Institution of Oceanography La Jolla, CA, United States)
Craig, Stephen
(Duke Univ. Durham, NC, United States)
Lin, Shirley
(Scripps Institution of Oceanography La Jolla, CA, United States)
Rudkevich, Dmitry M.
(Texas Univ. Arlington, TX, United States)
Rebek, Julius, Jr.
(Scripps Institution of Oceanography La Jolla, CA, United States)
Date Acquired
August 21, 2013
Publication Date
March 5, 2002
Publication Information
Publication: PNAS
Volume: 99
Issue: 5
Subject Category
Inorganic, Organic And Physical Chemistry
Funding Number(s)
CONTRACT_GRANT: NAG5-4546
Distribution Limits
Public
Copyright
Public Use Permitted.
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