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Record Details

Record 38 of 2350
Base-Pairing Systems Related to TNA: alpha-Threofuranosyl Oligonucleotides Containing Phosphoramidate Linkages
Author and Affiliation:
Meyer, Michael [Technical Monitor](NASA Goddard Space Flight Center, Greenbelt, MD, United States)
Wu, Xiaolin(Scripps Institution of Oceanography, Skaggs Research Foundation, La Jolla, CA, United States)
Guntha, Sreenivasulu(Scripps Institution of Oceanography, Skaggs Research Foundation, La Jolla, CA, United States)
Ferenclc, Mathias(Eidgenoessisches Flugzeugwerk, Zuerich, Switzerland)
Krishnamurthy, Ramanarayanan(Scripps Institution of Oceanography, Skaggs Inst. for Chemical Biology, La Jolla, CA, United States)
Eschenmoser, Albert(Scripps Institution of Oceanography, Skaggs Inst. for Chemical Biology, La Jolla, CA, United States)
Abstract: (3'NH)- and (2'NH)-TNA, two isomeric phosphoramidate analogues of TNA (alpha-threofuranosyl-(3'-2') oligonucleotides), are shown to be efficient Watson-Crick base-pairing systems and to undergo intersystem crosspairing with TNA, RNA, and DNA.
Publication Date: Jan 01, 2002
Document ID:
20030067894
(Acquired Sep 23, 2003)
Subject Category: INORGANIC, ORGANIC AND PHYSICAL CHEMISTRY
Document Type: Journal Article
Publication Information: Organic Letters; Volume 4; No. 8; 1279-1282
Contract/Grant/Task Num: NAG5-4546
Financial Sponsor: NASA Goddard Space Flight Center; Greenbelt, MD, United States
Austrian Science Fund; Vienna, Austria
Scripps Institution of Oceanography; Skaggs Research Foundation; La Jolla, CA, United States
Organization Source: Scripps Institution of Oceanography; La Jolla, CA, United States
Description: 4p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: DEOXYRIBONUCLEIC ACID; OLIGOMERS; ISOMERS; CHEMICAL REACTIONS; NUCLEOTIDES; ORGANIC PHOSPHORUS COMPOUNDS; HYDROLYSIS; SYNTHESIS (CHEMISTRY); TRANSCRIPTION (GENETICS); ULTRAVIOLET SPECTROSCOPY; NUCLEOSIDES
Availability Source: Other Sources
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