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Record 1 of 1683
A Simpler Nucleic Acid
Author and Affiliation:
Orgel, Leslie(Salk Inst. for Biological Studies, La Jolla, CA, United States)
Abstract: It has been supposed that for a nucleic acid analog to pair with RNA it must, like RNA, have a backbone with at least a sixatom repeat; a shorter backbone presumably would not stretch far enough to bind RNA properly. The Eschenmoser group has shown, however, that this first impression is incorrect.As they report in their new paper, Eschenmoser and co-workers ( I ) have now synthesized a substantial number of these polymers, which are called (L)-a-threofuranosyl oligonucleotides or TNAs. They are composed of bases linked to a threose sugar-phosphate backbone, with phosphodiester bonds connecting the nucleotides. The investigators discovered that pairs of complementary TNAs do indeed form stable Watson-Crick double helices and, perhaps more importantly, that TNAs form stable double helices with complementary RNAs and DNAs.
Publication Date: Jan 01, 2000
Document ID:
20030068036
(Acquired Sep 24, 2003)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Science; Volume 290; 1306-1307
Publisher Information: American Association for the Advancement of Science, United States
Contract/Grant/Task Num: NAG5-4546
Financial Sponsor: NASA Goddard Space Flight Center; Greenbelt, MD, United States
Organization Source: Salk Inst. for Biological Studies; La Jolla, CA, United States
Description: 3p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: RIBONUCLEIC ACIDS; EVOLUTION (DEVELOPMENT); BIOSYNTHESIS; SYNTHESIS (CHEMISTRY); TRANSCRIPTION (GENETICS); DEOXYRIBONUCLEIC ACID; REPLICAS
Availability Source: Other Sources
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