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Record 1 of 1
Physiological and Molecular Genetic Effects of Time-Varying Electromagnetic Fields on Human Neuronal Cells
NTRS Full-Text: Click to View  [PDF Size: 9.4 MB]
Author and Affiliation:
Goodwin, Thomas J.(NASA Johnson Space Center, Houston, TX, United States)
Abstract: The present investigation details the development of model systems for growing two- and three-dimensional human neural progenitor cells within a culture medium facilitated by a time-varying electromagnetic field (TVEMF). The cells and culture medium are contained within a two- or three-dimensional culture vessel, and the electromagnetic field is emitted from an electrode or coil. These studies further provide methods to promote neural tissue regeneration by means of culturing the neural cells in either configuration. Grown in two dimensions, neuronal cells extended longitudinally, forming tissue strands extending axially along and within electrodes comprising electrically conductive channels or guides through which a time-varying electrical current was conducted. In the three-dimensional aspect, exposure to TVEMF resulted in the development of three-dimensional aggregates, which emulated organized neural tissues. In both experimental configurations, the proliferation rate of the TVEMF cells was 2.5 to 4.0 times the rate of the non-waveform cells. Each of the experimental embodiments resulted in similar molecular genetic changes regarding the growth potential of the tissues as measured by gene chip analyses, which measured more than 10,000 human genes simultaneously.
Publication Date: Sep 01, 2003
Document ID:
20030075722
(Acquired Oct 09, 2003)
Subject Category: LIFE SCIENCES (GENERAL)
Report/Patent Number: NASA/TP-2003-212054, S-906, NAS 1.60:212054
Document Type: Technical Report
Financial Sponsor: NASA Johnson Space Center; Houston, TX, United States
Organization Source: NASA Johnson Space Center; Houston, TX, United States
Description: 38p; In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: No Copyright
NASA Terms: PHYSIOLOGICAL EFFECTS; ELECTROMAGNETIC FIELDS; GENES; NEURONS; LACTATES; MAMMALS; CULTURE TECHNIQUES; GLUCOSE
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