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Microsatellites in the Eukaryotic DNA Mismatch Repair Genes as Modulators of Evolutionary Mutation RateAll "minor" components of the human DNA mismatch repair (MMR) system-MSH3, MSH6, PMS2, and the recently discovered MLH3-contain mononucleotide microsatellites in their coding sequences. This intriguing finding contrasts with the situation found in the major components of the DNA MMR system-MSH2 and MLH1-and, in fact, most human genes. Although eukaryotic genomes are rich in microsatellites, non-triplet microsatellites are rare in coding regions. The recurring presence of exonal mononucleotide repeat sequences within a single family of human genes would therefore be considered exceptional.
Document ID
20030077901
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Chang, Dong Kyung (California Univ., San Diego La Jolla, CA, United States)
Metzgar, David (California Univ., San Diego La Jolla, CA, United States)
Wills, Christopher (California Univ., San Diego La Jolla, CA, United States)
Boland, C. Richard (California Univ., San Diego La Jolla, CA, United States)
Date Acquired
August 21, 2013
Publication Date
January 1, 2003
Publication Information
Publication: Genome Research
Volume: 11
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NAG5-4546
Distribution Limits
Public
Copyright
Other