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Radiation Dose-effects on Cell Cycle, Apoptosis, and Marker Expression of Ataxia Telangiectasia-Heterozygous Human Breast Epithelial CellsAtaxia-telangiectasia (A-T) is a radiation-sensitive genetic condition. AT-heterozygous human mammary epithelial cells (HMEC) were irradiated using a Cs137 source in order to compare cell cycle, apoptosis, and marker expression responses across 3 radiation doses. No differences in cell cycle and apoptosis were found with any of the radiation doses used (30, 60, and 90 rads) compared with the unirradiated control (0 rad). At the same doses, however, differences were found in marker expression, such as keratin 18 (kl8), keratin 14 (k14), insulin-like growth factor I receptor (IGF-IR), and connexin 43 (cx43). This may indicate that radiation sensitivity in the heterozygous state may be initiated through signal transduction responses.
Document ID
20040000555
Acquisition Source
Marshall Space Flight Center
Document Type
Conference Paper
Authors
Cruz, A.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Bors, K.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Jansen, H.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Richmond, R.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Date Acquired
August 21, 2013
Publication Date
January 1, 2003
Subject Category
Life Sciences (General)
Meeting Information
Meeting: 5th Annual Biological Sciences Retreat
Location: Guntersville, AL
Country: United States
Start Date: October 11, 2003
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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