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Development of Laser-Polarized Noble Gas Magnetic Resonance Imaging (MRI) TechnologyWe are developing technology for laser-polarized noble gas nuclear magnetic resonance (NMR), with the aim of enabling it as a novel biomedical imaging tool for ground-based and eventually space-based application. This emerging multidisciplinary technology enables high-resolution gas-space magnetic resonance imaging (MRI)-e.g., of lung ventilation, perfusion, and gas-exchange. In addition, laser-polarized noble gases (3He and 1BXe) do not require a large magnetic field for sensitive NMR detection, opening the door to practical MRI with novel, open-access magnet designs at very low magnetic fields (and hence in confined spaces). We are pursuing two specific aims in this technology development program. The first aim is to develop an open-access, low-field (less than 0.01 T) instrument for MRI studies of human gas inhalation as a function of subject orientation, and the second aim is to develop functional imaging of the lung using laser-polarized He-3 and Xe-129.
Document ID
Document Type
Contractor or Grantee Report
Walsworth, Ronald L.
(Smithsonian Astrophysical Observatory Cambridge, MA, United States)
Date Acquired
August 21, 2013
Publication Date
March 1, 2004
Subject Category
Instrumentation And Photography
Funding Number(s)
Distribution Limits
Work of the US Gov. Public Use Permitted.
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