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Systematic Sensitivity Analysis of Metabolic Controllers During Reductions in Skeletal Muscle Blood FlowAn acute reduction in oxygen delivery to skeletal muscle is generally associated with profound derangements in substrate metabolism. Given the complexity of the human bioenergetic system and its components, it is difficult to quantify the interaction of cellular metabolic processes to maintain ATP homeostasis during stress (e.g., hypoxia, ischemia, and exercise). Of special interest is the determination of mechanisms relating tissue oxygenation to observed metabolic responses at the tissue, organ, and whole body levels and the quantification of how changes in oxygen availability affect the pathways of ATP synthesis and their regulation. In this study, we apply a previously developed mathematical model of human bioenergetics to study effects of ischemia during periods of increased ATP turnover (e.g., exercise). By using systematic sensitivity analysis the oxidative phosphorylation rate was found to be the most important rate parameter affecting lactate production during ischemia under resting conditions. Here we examine whether mild exercise under ischemic conditions alters the relative importance of pathways and parameters previously obtained.
Document ID
20040045304
Document Type
Reprint (Version printed in journal)
Authors
Radhakrishnan, Krishnan (Ohio Aerospace Inst. Cleveland, OH, United States)
Cabrera, Marco (Case Western Reserve Univ. Cleveland, OH, United States)
Date Acquired
August 21, 2013
Publication Date
January 1, 2000
Publication Information
Publication: Annals of Biomedical Engineering
Subject Category
Life Sciences (General)
Report/Patent Number
T9.21
Meeting Information
Biomedical Engineering Society 2000 Annual Fall Meeting(Seattle, WA)
Funding Number(s)
CONTRACT_GRANT: NCC3-782
Distribution Limits
Public
Copyright
Other