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Are Samples Obtained after Return to Earth Reflective of Spaceflight or Increased Gravity?Upon return to Earth, following space flight, living systems are immediately exposed to an increase in gravity of 1G. It has been difficult to differentiate between changes that are residuals of the acclimation to space flight from those resulting from acute exposure to an increase in =gravity upon re-entry. We compared previously reported changes observed in male Sprague-Dawley rats upon return to Earth to those induced by centrifugation, because both paradigms result in an increase of 1G. With both treatments there was a reduction in body mass, due to reduced food intake and increased urine output. The decrease in food intake was initially greater with centrifugation. The magnitudes of the changes in food intake and urine output were similar in both treatments. However, the slightly greater initial loss in body mass with centrifugation was due to a decrease in water intake not seen after space flight. The absence of pronounced differences between these treatments suggest the responses observed after landing are not residuals of adaptation to the space flight environment, but the result of adaptation to an increase in the level of gravity.
Document ID
Document Type
Preprint (Draft being sent to journal)
Wade, C. R.
Holton, E.
Baer, L.
Moran, M.
Date Acquired
August 21, 2013
Publication Date
January 1, 2001
Subject Category
Life Sciences (General)
Funding Number(s)
OTHER: 121-40-10
OTHER: 121-10-30
OTHER: 121-10-40
OTHER: 121-10-50
Distribution Limits
Work of the US Gov. Public Use Permitted.