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Hypergravity-Induced Changes in Hematological and Lymphocyte Function Parameters in a Mouse ModelThe purpose of this study was to quantify hypergravity-induced changes in hematological and lymphocyte characteristics. Mice were subjected to 1, 2, and 3G and euthanized on days 1 , 4, 7, 10, and 21. The data show that increased gravitational force resulted in persistent hypothermia. Red blood cell (RBC) counts, hematocrit, and hemoglobin were reduced by day 21, whereas hemoglobin and RBC volume were low at most times of measurement. A transient increase was noted in platelet numbers in the 3G group. Fluctuations in spontaneous blastogenesis of lymphocytes were dependent upon centrifugation time and not gravity. Changes in splenocyte responses to T and B cell mitogens due to gravity were also noted. Cytokine production was primarily affected during the first week; IL-2, IL-4 and TNF-alpha were increased, whereas IFN-gamma was decreased. These findings indicate that altered gravity can influence both hematological and functional variables that may translate into serious health consequences.
Document ID
Acquisition Source
Document Type
Reprint (Version printed in journal)
Gridley, Daila S.
(Loma Linda Univ. CA, United States)
Miller, Glen M.
(Loma Linda Univ. CA, United States)
Nelson, Gregory A.
(Loma Linda Univ. CA, United States)
Pecaut, Michael J.
(Loma Linda Univ. CA, United States)
Date Acquired
August 21, 2013
Publication Date
July 1, 2003
Publication Information
Publication: Journal of Gravitational Physiology
Publisher: Galileo Foundation
Volume: 10
Issue: 1
ISSN: 1077-9248
Subject Category
Life Sciences (General)
Meeting Information
Meeting: 24th Annual Gravitational Physiology Meeting
Location: Santa Monica, CA
Country: United States
Start Date: May 4, 2003
End Date: May 9, 2003
Sponsors: International Society for Gravitational Physiology
Funding Number(s)
Distribution Limits
Public Use Permitted.
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