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The Hematopoietic Stem Cell Therapy for Exploration of Deep SpaceIt is hypothesized that the hematopoietic stem cell therapy (HSCT) might countermeasure various space-caused disorders so as to maintain astronauts' homeostasis. If this were achievable, the HSCT could promote human exploration of deep space. Using animal models of disorders (hindlimb suspension unloading system and beta-thalassemia), the HSCT was tested for muscle loss, immunodeficiency and space anemia. The results indicate feasibility of HSCT for these disorders. To facilitate the HSCT in space, growth of HSCs were optimized in the NASA Rotating Wall Vessel (RWV) culture systems, including Hydrodynamic Focusing Bioreactor (HFB).
Document ID
20040070923
Document Type
Reprint (Version printed in journal)
Authors
Ohi, Seigo (Howard Univ. Washington, DC, United States)
Roach, Allana-Nicole (Howard Univ. Washington, DC, United States)
Fitzgerald, Wendy (NASA Headquarters Washington, DC United States)
Riley, Danny A. (Medical Coll. of Wisconsin Milwaukee, WI, United States)
Gonda, Steven R. (NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 21, 2013
Publication Date
July 1, 2003
Publication Information
Publication: Journal of Gravitational Physiology
Volume: 10
Issue: 1
ISSN: 1077-9248
Subject Category
Life Sciences (General)
Meeting Information
24th Annual Gravitational Physiology Meeting(Santa Monica, CA)
Funding Number(s)
CONTRACT_GRANT: NCC9-142
CONTRACT_GRANT: NAS5-98051
CONTRACT_GRANT: NAG2-6072
Distribution Limits
Public
Copyright
Other