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Effects of Hindlimb Unweighting on Arterial Contractile Responses in MiceThe aim of this work was to determine if hindlimb unweighting in mice alters arterial contractile responses. Sixteen male C57B/6 mice and 16 male Chinese Kunming mice were divided into control and 3 weeks hindlimb unweighting groups, respectively. Using isolated arterial rings from different arteries of mouse, effects of 3 weeks hindlimb unweighting on arterial contractile responsiveness were examined in vitro. The results showed that, in arterial rings from both C57B/6 and Chinese Kunming mice, maximum isometric contractile tensions evoked by either KCl or phenylephrine were significantly lower in abdominal aortic, mesenteric arterial and femoral arterial rings from hindlimb unweighting, compared to control mice. However, the maximal contractile responses of common carotid rings to KCl and PE were not significantly different between control and hindlimb unweighting groups. The sensitivity (EC(sub 50)) of all arteries to KCl or PE showed no significant differences between control and hindlimb unweighting mice. These data indicated that 3 weeks hindlimb unweighting results in a reduced capacity of the arterial smooth muscle of the hindquarter to develop tension. In addition, the alterations in arterial contractile responses caused by hindlimb unweighting in mice are similar as those in rats. Our work suggested that hindlimb unweighting mouse model may be used as a model for the study of postflight cardiovascular deconditioning.
Document ID
20040070928
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
Authors
Ma, Jia
(California Univ. Irvine, CA, United States)
Ren, Xin-Ling
(California Univ. Irvine, CA, United States)
Purdy, Ralph E.
(California Univ. Irvine, CA, United States)
Date Acquired
August 21, 2013
Publication Date
July 1, 2003
Publication Information
Publication: Journal of Gravitational Physiology
Publisher: Galileo Foundation
Volume: 10
Issue: 1
ISSN: 1077-9248
Subject Category
Life Sciences (General)
Meeting Information
Meeting: 24th Annual Gravitational Physiology Meeting
Location: Santa Monica, CA
Country: United States
Start Date: May 4, 2003
End Date: May 9, 2003
Sponsors: International Society for Gravitational Physiology
Funding Number(s)
CONTRACT_GRANT: NAG2-6072
CONTRACT_GRANT: NAG9-1149
Distribution Limits
Public
Copyright
Other

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