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Pulsed Phase Lock Loop Device for Monitoring Intracranial Pressure During Space FlightWe have developed an ultrasonic device to monitor ICP waveforms non-invasively from cranial diameter oscillations using a NASA-developed pulsed phase lock loop (PPLL) technique. The purpose of this study was to attempt to validate the PPLL device for reliable recordings of ICP waveforms and analysis of ICP dynamics in vivo. METHODS: PPLL outputs were recorded in patients during invasive ICP monitoring at UCSD Medical Center (n=10). RESULTS: An averaged linear regression coefficient between ICP and PPLL waveform data during one cardiac cycle in all patients is 0.88 +/- 0.02 (mean +/- SE). Coherence function analysis indicated that ICP and PPLL waveforms have high correlation in the lst, 2nd, and 3rd harmonic waves associated with a cardiac cycle. CONCLUSIONS: PPLL outputs represent ICP waveforms in both frequency and time domains. PPLL technology enables in vivo evaluation of ICP dynamics non-invasively, and can acquire continuous ICP waveforms during spaceflight because of compactness and non-invasive nature.
Document ID
20040070932
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
Authors
Ueno, Toshiaki
(California Univ. San Diego, CA, United States)
Macias, Brandon R.
(California Univ. San Diego, CA, United States)
Yost, William T.
(NASA Langley Research Center Hampton, VA, United States)
Hargens, Alan R.
(California Univ. San Diego, CA, United States)
Date Acquired
August 21, 2013
Publication Date
July 1, 2003
Publication Information
Publication: Journal of Gravitational Physiology
Publisher: Galileo Foundation
Volume: 10
Issue: 1
ISSN: 1077-9248
Subject Category
Life Sciences (General)
Meeting Information
Meeting: 24th Annual Gravitational Physiology Meeting
Location: Santa Monica, CA
Country: United States
Start Date: May 4, 2003
End Date: May 9, 2003
Sponsors: International Society for Gravitational Physiology
Funding Number(s)
CONTRACT_GRANT: NAG2-6072
CONTRACT_GRANT: NAG1-02092
CONTRACT_GRANT: NCC2-1196
Distribution Limits
Public
Copyright
Other

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