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Kinetic Roughening Transition and Energetics of Tetragonal Lysozyme Crystal GrowthInterpretation of lysozyme crystal growth rates using well-established physical theories enabled the discovery of a phenomenon possibly indicative of kinetic roughening. For example, lysozyme crystals grown above a critical supersaturation sigma, (where supersaturation sigma = ln c/c(sub eq), c = the protein concentration and c(sub eq) = the solubility concentration) exhibit microscopically rough surfaces due to the continuous addition of growth units anywhere on the surface of a crystal. The rate of crystal growth, V(sub c), for the continuous growth process is determined by the continuous flux of macromolecules onto a unit area of the crystal surface, a, from a distance, xi, per unit time due to diffusion, and a probability of attachment onto the crystal surface, expressed. Based upon models applied, the energetics of lysozyme crystal growth was determined. The magnitudes of the energy barriers of crystal growth for both the (110) and (101) faces of tetragonal lysozyme crystals are compared. Finally, evidence supportive of the kinetic roughening hypothesis is presented.
Document ID
Acquisition Source
Marshall Space Flight Center
Document Type
Conference Paper
Gorti, Sridhar
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Forsythe, Elizabeth L.
(BAE Systems Fairfax, VA, United States)
Pusey, Marc L.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Date Acquired
August 21, 2013
Publication Date
January 1, 2004
Subject Category
Solid-State Physics
Meeting Information
Meeting: 10th International Conference on the Crystallization of Biological Macromolecules
Location: Beijing
Country: China
Start Date: June 5, 2004
End Date: June 8, 2004
Distribution Limits
Work of the US Gov. Public Use Permitted.

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