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Which strategy for a protein crystallization project?The three-dimensional, atomic-resolution protein structures produced by X-ray crystallography over the past 50+ years have led to tremendous chemical understanding of fundamental biochemical processes. The pace of discovery in protein crystallography has increased greatly with advances in molecular biology, crystallization techniques, cryocrystallography, area detectors, synchrotrons and computing. While the methods used to produce single, well-ordered crystals have also evolved over the years in response to increased understanding and advancing technology, crystallization strategies continue to be rooted in trial-and-error approaches. This review summarizes the current approaches in protein crystallization and surveys the first results to emerge from the structural genomics efforts.
Document ID
20040087403
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kundrot, C. E.
(NASA Marshall Space Flight Center Huntsville AL United States)
Date Acquired
August 21, 2013
Publication Date
March 1, 2004
Publication Information
Publication: Cellular and molecular life sciences : CMLS
Volume: 61
Issue: 5
ISSN: 1420-682X
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review
Review, Tutorial

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