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Effects of prolonged bed rest on the total peripheral resistance baroreflexOrthostatic intolerance following prolonged exposure to microgravity continues to be a primary concern of the human space program. Reduced autonomic tone has been demonstrated to contribute to this phenomenon, and the heart rate baroreflex, in particular, has been repeatedly shown to be impaired. However, only the works of Yelle et al. have attempted to address the role of the total peripheral resistance (TPR) baroreflex, a potentially more significant contributor to blood pressure regulation. We applied a previously developed method for estimating the static gains of both the arterial and cardiopulmonary TPR baroreflexes to data obtained before and after 16-day bed rest. Reductions in the estimated static gains of the arterial (statistically significant) and cardiopulmonary TPR baroreflexes were found after bed rest. This study supports the works of Yelle et al, which imply that the TPR baroreflex is reduced after spaceflight.
Document ID
20040087426
Acquisition Source
Goddard Space Flight Center
Document Type
Reprint (Version printed in journal)
Authors
Xiao, X.
(Harvard-MIT Division of Health Sciences and Technology Cambridge, MA, United States)
Mukkamala, R.
Sheynberg, N.
Williams, G. H.
Cohen, R. J.
Mark, R. G.
Date Acquired
August 21, 2013
Publication Date
January 1, 2002
Publication Information
Publication: Computers in cardiology
Volume: 29
ISSN: 0276-6574
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: NAG5-4989
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Program Biomedical Research and Countermeasures
NASA Discipline Cardiopulmonary

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