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Relationship between systolic and diastolic function with improvements in forward stroke volume following reduction in mitral regurgitationEfforts to improve mitral regurgitation (MR) are often performed in conjunction with coronary revascularization. However, the independent effects of a reduced MR area (MRa) are difficult to quantify. Using a previously developed cardiovascular model, ventricular contractility (elastance 1-8 mmHg/ml) and relaxation (tau: 40-150 msec) were independently adjusted for four grades of MR orifice areas (0.0 to 0.8 cm2). Improvements in forward stroke volume (fSV) were determined for the permutations of reduced MRa. For all conditions, LV end-diastolic pressure and volumes ranged from 7.3-24.2 mmHg and 64.8-174.3 ml, respectively. Overall, fSV ranged from 36.0-89.4 (mean: 64.2 +/- 12.8) ml, improved between 6.4 and 35.3% (mean: 15.6 +/- 8.1%), and was best predicted by (r=0.97, p<0.01) %delta(fSV)[correction of fVS]=34[MRa initial] - 46[MRa final] -0.5[elastance]. Reduced MRa, independent of relaxation and minimally influence by contractility, yield improved fSVs.
Document ID
20040087458
Acquisition Source
Johnson Space Center
Document Type
Reprint (Version printed in journal)
Authors
Firstenberg, M. S.
(The Cleveland Clinic Foundation Cleveland, United States)
Greenberg, N. L.
Smedira, N. G.
McCarthy, P. M.
Garcia, M. J.
Thomas, J. D.
Date Acquired
August 21, 2013
Publication Date
January 1, 2001
Publication Information
Publication: Computers in cardiology
Volume: 28
ISSN: 0276-6574
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NCC9-58
CONTRACT_GRANT: NCC9-60
CONTRACT_GRANT: 1R01HL56688-01A1
CONTRACT_GRANT: AHA 93-13880
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cardiopulmonary
Non-NASA Center
NASA Program Biomedical Research and Countermeasures

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