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Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation?A number of nontargeted and delayed effects associated with radiation exposure have now been described. These include radiation-induced genomic instability, death-inducing and bystander effects, clastogenic factors and transgenerational effects. It is unlikely that these nontargeted effects are directly induced by cellular irradiation. Instead, it is proposed that some as yet to be identified secreted factor can be produced by irradiated cells that can stimulate effects in nonirradiated cells (death-inducing and bystander effects, clastogenic factors) and perpetuate genomic instability in the clonally expanded progeny of an irradiated cell. The proposed factor must be soluble and capable of being transported between cells by cell-to-cell gap junction communication channels. Furthermore, it must have the potential to stimulate cellular cytokines and/or reactive oxygen species. While it is difficult to imagine a role for such a secreted factor in contributing to transgenerational effects, the other nontargeted effects of radiation may all share a common mechanism.
Document ID
20040087493
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Morgan, William F. (University of Maryland 655 W. Baltimore St., BRB 7-011, Baltimore, MD 21201-5525, United States)
Date Acquired
August 21, 2013
Publication Date
October 13, 2003
Publication Information
Publication: Oncogene
Volume: 22
Issue: 45
ISSN: 0950-9232
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: CA 83872
CONTRACT_GRANT: CA73924
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
Review, Tutorial
NASA Program Biomedical Research and Countermeasures
NASA Discipline Radiation Health
Review