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Record 2 of 121
Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases
Author and Affiliation:
Boo, Yong Chool(Georgia Tech and Emory University, Wallace H. Coulter Department of Biomedical Engineering, Atlanta, GA 30322, United States)
Jo, Hanjoong
Abstract: Vascular endothelial cells are directly and continuously exposed to fluid shear stress generated by blood flow. Shear stress regulates endothelial structure and function by controlling expression of mechanosensitive genes and production of vasoactive factors such as nitric oxide (NO). Though it is well known that shear stress stimulates NO production from endothelial nitric oxide synthase (eNOS), the underlying molecular mechanisms remain unclear and controversial. Shear-induced production of NO involves Ca2+/calmodulin-independent mechanisms, including phosphorylation of eNOS at several sites and its interaction with other proteins, including caveolin and heat shock protein-90. There have been conflicting results as to which protein kinases-protein kinase A, protein kinase B (Akt), other Ser/Thr protein kinases, or tyrosine kinases-are responsible for shear-dependent eNOS regulation. The functional significance of each phosphorylation site is still unclear. We have attempted to summarize the current status of understanding in shear-dependent eNOS regulation.
Publication Date: Sep 01, 2003
Document ID:
20040087572
(Acquired Sep 07, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: American journal of physiology. Cell physiology; p. C499-508; (ISSN 0363-6143); Volume 285; 3
Publisher Information: United States
Contract/Grant/Task Num: HL-67413; HL-70531; HL-71014
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ENDOTHELIUM; ENZYMES; NITRIC OXIDE; PROTEINS; PULSES; STRESSES; UNSTEADY FLOW
Other Descriptors: ENDOTHELIUM, VASCULAR/ENZYMOLOGY; NITRIC-OXIDE SYNTHASE/METABOLISM; PROTEIN KINASES/METABOLISM; ANIMALS; PULSATILE FLOW/PHYSIOLOGY; STRESS, MECHANICAL; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; REVIEW; REVIEW LITERATURE; NASA DISCIPLINE CELL BIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
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