NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Neuroprotection trek--the next generation: neuromodulation II. Applications--epilepsy, nerve regeneration, neurotrophinsThree examples of neuroprotective applications of electrical stimulation-neuromodulation-are considered: (1) the diagnosis and treatment of epilepsy, (2) the augmentation of peripheral nerve regeneration after transection, and (3) the interaction between electrical stimulation and neurotrophins (notably brain derived neurotrophic factor [BDNF]) in various neuroprotective situations. The research cited demonstrates clear benefit from appropriate electrical stimulation in the treatment of (1) certain patients with medication-refractory epilepsy, and (2) the functional regeneration of peripheral nerves after transection and surgical repair. Furthermore, neuromodulation of peripheral nerve regeneration has been associated with an increase in the neurotrophin BDNF. The roles of BDNF and other neurotrophins in several disorders of the nervous system are discussed in the context of neuromodulation and its augmentation of neurotrophins. Neuromodulation-at least in part through its effect on BDNF and other neurotrophins-will likely play a major role in the treatment (and possibly prevention) of disorders of the nervous system for which neuroproteive pharmacologic agents have traditionally been sought.
Document ID
20040087602
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Andrews, Russell J.
(NASA Ames Research Center Moffett Field CA United States)
Date Acquired
August 21, 2013
Publication Date
May 1, 2003
Publication Information
Publication: Annals of the New York Academy of Sciences
Volume: 993
ISSN: 0077-8923
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review
Review, Tutorial

Available Downloads

There are no available downloads for this record.
No Preview Available