NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Loss of T cell precursors after spaceflight and exposure to vector-averaged gravityUsing fetal thymus organ culture (FTOC), we examined the effects of spaceflight and vector-averaged gravity on T cell development. Under both conditions, the development of T cells was significantly attenuated. Exposure to spaceflight for 16 days resulted in a loss of precursors for CD4+, CD8+, and CD4+CD8+ T cells in a rat/mouse xenogeneic co-culture. A significant decrease in the same precursor cells, as well as a decrease in CD4-CD8- T cell precursors, was also observed in a murine C57BL/6 FTOC after rotation in a clinostat to produce a vector-averaged microgravity-like environment. The block in T cell development appeared to occur between the pre-T cell and CD4+CD8+ T cell stage. These data indicate that gravity plays a decisive role in the development of T cells.
Document ID
20040087621
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Woods, Chris C.
(University of Arizona Tucson, Arizona 85724, United States)
Banks, Krista E.
Gruener, Raphael
DeLuca, Dominick
Date Acquired
August 21, 2013
Publication Date
August 1, 2003
Publication Information
Publication: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume: 17
Issue: 11
ISSN: 0892-6638
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Flight Experiment
short duration
Non-NASA Center
manned
NASA Discipline Developmental Biology
STS-90 Shuttle Project

Available Downloads

There are no available downloads for this record.
No Preview Available