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Clustered DNA damages induced in human hematopoietic cells by low doses of ionizing radiationIonizing radiation induces clusters of DNA damages--oxidized bases, abasic sites and strand breaks--on opposing strands within a few helical turns. Such damages have been postulated to be difficult to repair, as are double strand breaks (one type of cluster). We have shown that low doses of low and high linear energy transfer (LET) radiation induce such damage clusters in human cells. In human cells, DSB are about 30% of the total of complex damages, and the levels of DSBs and oxidized pyrimidine clusters are similar. The dose responses for cluster induction in cells can be described by a linear relationship, implying that even low doses of ionizing radiation can produce clustered damages. Studies are in progress to determine whether clusters can be produced by mechanisms other than ionizing radiation, as well as the levels of various cluster types formed by low and high LET radiation.
Document ID
20040087650
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Sutherland, Betsy M. (Brookhaven National Laboratory Upton, NY 11973-5000, United States)
Bennett, Paula V.
Cintron-Torres, Nela
Hada, Megumi
Trunk, John
Monteleone, Denise
Sutherland, John C.
Laval, Jacques
Stanislaus, Marisha
Gewirtz, Alan
Date Acquired
August 21, 2013
Publication Date
December 1, 2002
Publication Information
Publication: Journal of radiation research
Volume: 43 Suppl
ISSN: 0449-3060
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: R01 CA86987
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Radiation Health
Non-NASA Center