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Expression and function of FGF10 in mammalian inner ear developmentWe have investigated the expression of FGF10 during ear development and the effect of an FGF10 null mutation on ear development. Our in situ hybridization data reveal expression of FGF10 in all three canal crista sensory epithelia and the cochlea anlage as well as all sensory neurons at embryonic day 11.5 (E11.5). Older embryos (E18.5) displayed strong graded expression in all sensory epithelia. FGF10 null mutants show complete agenesis of the posterior canal crista and the posterior canal. The posterior canal sensory neurons form initially and project rather normally by E11.5, but they disappear within 2 days. FGF10 null mutants have no posterior canal system at E18.5. In addition, these mutants have deformations of the anterior and horizontal cristae, reduced formation of the anterior and horizontal canals, as well as altered position of the remaining sensory epithelia with respect to the utricle. Hair cells form but some have defects in their cilia formation. No defects were detected in the organ of Corti at the cellular level. Together these data suggest that FGF10 plays a major role in ear morphogenesis. Most of these data are consistent with earlier findings on a null mutation in FGFR2b, one of FGF10's main receptors. Copyright 2003 Wiley-Liss, Inc.
Document ID
20040087684
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Pauley, Sarah
(Creighton University, Department of Biomedical Sciences Omaha, Nebraska 68178, United States)
Wright, Tracy J.
Pirvola, Ulla
Ornitz, David
Beisel, Kirk
Fritzsch, Bernd
Date Acquired
August 21, 2013
Publication Date
June 1, 2003
Publication Information
Publication: Developmental dynamics : an official publication of the American Association of Anatomists
Volume: 227
Issue: 2
ISSN: 1058-8388
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: R01 DC005590
CONTRACT_GRANT: R01 CA60673
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Developmental Biology
Non-NASA Center
NASA Program Fundamental Space Biology

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