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The plasma membrane-associated NADH oxidase (ECTO-NOX) of mouse skin responds to blue lightNADH oxidases of the external plasma membrane surface (ECTO-NOX proteins) are characterized by oscillations in activity with a regular period length of 24 min. Explants of mouse skin exhibit the oscillatory activity as estimated from the decrease in A(340) suggesting that individual ECTO-NOX molecules must somehow be induced to function synchronously. Transfer of explants of mouse skin from darkness to blue light (495 nm, 2 min, 50 micromol m(-1) s(-1)) resulted in initiation of a new activity maximum (entrainment) with a midpoint 36 min after light exposure followed by maxima every 24 min thereafter. Addition of melatonin resulted in a new maximum 24 min after melatonin addition. The findings suggest that the ECTO-NOX proteins play a central role in the entrainment of the biological clock both by light and by melatonin.
Document ID
Document Type
Reprint (Version printed in journal)
Morre, D. James
(201 S. University Street West Lafayette, IN 47907-2064, United States)
Morre, Dorothy M.
Date Acquired
August 21, 2013
Publication Date
April 1, 2003
Publication Information
Publication: Journal of photochemistry and photobiology. B, Biology
Volume: 70
Issue: 1
ISSN: 1011-1344
Subject Category
Life Sciences (General)
Distribution Limits
NASA Discipline Cell Biology
Non-NASA Center

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