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Common endocrine control of body weight, reproduction, and bone massBone mass is maintained constant between puberty and menopause by the balance between osteoblast and osteoclast activity. The existence of a hormonal control of osteoblast activity has been speculated for years by analogy to osteoclast biology. Through the search for such humoral signal(s) regulating bone formation, leptin has been identified as a strong inhibitor of bone formation. Furthermore, intracerebroventricular infusion of leptin has shown that the effect of this adipocyte-derived hormone on bone is mediated via a brain relay. Subsequent studies have led to the identification of hypothalamic groups of neurons involved in leptin's antiosteogenic function. In addition, those neurons or neuronal pathways are distinct from neurons responsible for the regulation of energy metabolism. Finally, the peripheral mediator of leptin's antiosteogenic function has been identified as the sympathetic nervous system. Sympathomimetics administered to mice decreased bone formation and bone mass. Conversely, beta-blockers increased bone formation and bone mass and blunted the bone loss induced by ovariectomy.
Document ID
20040087710
Document Type
Reprint (Version printed in journal)
Authors
Takeda, Shu (Baylor College of Medicine Houston, Texas 77030, United States)
Elefteriou, Florent
Karsenty, Gerard
Date Acquired
August 21, 2013
Publication Date
January 1, 2003
Publication Information
Publication: Annual review of nutrition
Volume: 23
ISSN: 0199-9885
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
Review
NASA Program Biomedical Research and Countermeasures
Non-NASA Center
Review, Tutorial