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Record 10 of 260
The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: a 14-month longitudinal study
External Online Source: doi:10.1086/374739
Author and Affiliation:
Ling, Paul D.(Baylor College of Medicine, Department of Molecular Virology and Microbiology, Houston, Texas 77030, United States)
Lednicky, John A.
Keitel, Wendy A.
Poston, David G.
White, Zoe S.
Peng, RongSheng
Liu, Zhensheng
Mehta, Satish K.
Pierson, Duane L.
Rooney, Cliona M. Show more authors
Abstract: Humans are infected with viruses that establish long-term persistent infections. To address whether immunocompetent individuals control virus reactivation globally or independently and to identify patterns of sporadic reactivation, we monitored herpesviruses and polyomaviruses in 30 adults, over 14 months. Epstein-Barr virus (EBV) DNA was quantitated in saliva and peripheral blood mononuclear cells (PBMCs), cytomegalovirus (CMV) was assayed in urine, and JC virus (JCV) and BK virus (BKV) DNAs were assayed in urine and PBMCs. All individuals shed EBV in saliva, whereas 67% had >or=1 blood sample positive for EBV. Levels of EBV varied widely. CMV shedding occurred infrequently but occurred more commonly in younger individuals (P<.03). JCV and BKV virurias were 46.7% and 0%, respectively. JCV shedding was age dependent and occurred commonly in individuals >or=40 years old (P<.03). Seasonal variation was observed in shedding of EBV and JCV, but there was no correlation among shedding of EBV, CMV, and JCV (P>.50). Thus, adults independently control persistent viruses, which display discordant, sporadic reactivations.
Publication Date: May 15, 2003
Document ID:
20040087716
(Acquired Sep 07, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: The Journal of infectious diseases (ISSN 0022-1899); Volume 187; 10; 1571-80
Publisher Information: United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: VIRUSES; ADULTS; AGE FACTOR; BLOOD; DEOXYRIBONUCLEIC ACID; FEMALES; GENETICS; LEUKOCYTES; MALES; SALIVA; SEASONS; TIME DEPENDENCE; URINE
Other Descriptors: BK VIRUS/ISOLATION & PURIFICATION/PHYSIOLOGY; CYTOMEGALOVIRUS/ISOLATION & PURIFICATION/PHYSIOLOGY; HERPESVIRUS 4, HUMAN/GENETICS/ISOLATION & PURIFICATION/PHYSIOLOGY; JC VIRUS/GENETICS/ISOLATION & PURIFICATION/PHYSIOLOGY; VIRUS ACTIVATION; VIRUS SHEDDING; ADULT; AGE FACTORS; BASE SEQUENCE; DNA, VIRAL/ANALYSIS/BLOOD/URINE; FEMALE; HUMAN; LEUKOCYTES, MONONUCLEAR/VIROLOGY; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; SALIVA/VIROLOGY; SEASONS; SUPPORT, U.S. GOV'T, NON-P.H.S; TIME FACTORS; URINE/VIROLOGY; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
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