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The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: a 14-month longitudinal studyHumans are infected with viruses that establish long-term persistent infections. To address whether immunocompetent individuals control virus reactivation globally or independently and to identify patterns of sporadic reactivation, we monitored herpesviruses and polyomaviruses in 30 adults, over 14 months. Epstein-Barr virus (EBV) DNA was quantitated in saliva and peripheral blood mononuclear cells (PBMCs), cytomegalovirus (CMV) was assayed in urine, and JC virus (JCV) and BK virus (BKV) DNAs were assayed in urine and PBMCs. All individuals shed EBV in saliva, whereas 67% had >or=1 blood sample positive for EBV. Levels of EBV varied widely. CMV shedding occurred infrequently but occurred more commonly in younger individuals (P<.03). JCV and BKV virurias were 46.7% and 0%, respectively. JCV shedding was age dependent and occurred commonly in individuals >or=40 years old (P<.03). Seasonal variation was observed in shedding of EBV and JCV, but there was no correlation among shedding of EBV, CMV, and JCV (P>.50). Thus, adults independently control persistent viruses, which display discordant, sporadic reactivations.
Document ID
Document Type
Reprint (Version printed in journal)
External Source(s)
Ling, Paul D. (Baylor College of Medicine Houston, Texas 77030, United States)
Lednicky, John A.
Keitel, Wendy A.
Poston, David G.
White, Zoe S.
Peng, RongSheng
Liu, Zhensheng
Mehta, Satish K.
Pierson, Duane L.
Rooney, Cliona M.
Vilchez, Regis A.
Smith, E. O'Brian
Butel, Janet S.
Date Acquired
August 21, 2013
Publication Date
May 15, 2003
Publication Information
Publication: The Journal of infectious diseases
Volume: 187
Issue: 10
ISSN: 0022-1899
Subject Category
Life Sciences (General)
Distribution Limits
Non-NASA Center
NASA Discipline Regulatory Physiology