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Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effectsThe goal of this review is to summarize the evidence for non-targeted and delayed effects of exposure to ionizing radiation in vivo. Currently, human health risks associated with radiation exposures are based primarily on the assumption that the detrimental effects of radiation occur in irradiated cells. Over the years a number of non-targeted effects of radiation exposure in vivo have been described that challenge this concept. These include radiation-induced genomic instability, bystander effects, clastogenic factors produced in plasma from irradiated individuals that can cause chromosomal damage when cultured with nonirradiated cells, and transgenerational effects of parental irradiation that can manifest in the progeny. These effects pose new challenges to evaluating the risk(s) associated with radiation exposure and understanding radiation-induced carcinogenesis.
Document ID
20040087726
Document Type
Reprint (Version printed in journal)
Authors
Morgan, William F. (University of Maryland Baltimore, Maryland 21201-5525, United States)
Date Acquired
August 21, 2013
Publication Date
May 1, 2003
Publication Information
Publication: Radiation research
Volume: 159
Issue: 5
ISSN: 0033-7587
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: CA 83872
CONTRACT_GRANT: CA 73924
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
Non-NASA Center
Review
NASA Discipline Radiation Health