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Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitroA long-standing dogma in the radiation sciences is that energy from radiation must be deposited in the cell nucleus to elicit a biological effect. A number of non-targeted, delayed effects of ionizing radiation have been described that challenge this dogma and pose new challenges to evaluating potential hazards associated with radiation exposure. These effects include induced genomic instability and non-targeted bystander effects. The in vitro evidence for non-targeted effects in radiation biology will be reviewed, but the question as to how one extrapolates from these in vitro observations to the risk of radiation-induced adverse health effects such as cancer remains open.
Document ID
20040087727
Document Type
Reprint (Version printed in journal)
Authors
Morgan, William F. (University of Maryland Baltimore, Maryland 21201-5525, United States)
Date Acquired
August 21, 2013
Publication Date
May 1, 2003
Publication Information
Publication: Radiation research
Volume: 159
Issue: 5
ISSN: 0033-7587
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: CA 83872
CONTRACT_GRANT: CA73924
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
Non-NASA Center
NASA Discipline Radiation Health
Review