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Dependence of normal development of skeletal muscle in neonatal rats on load bearingAntigravity function plays an important role in determining the morphological and physiological properties of the neuromuscular system. Inhibition of the normal development of the neuromuscular system is induced by hindlimb unloading during the neonatal period in rats. However, the role of gravitational loading on the development of skeletal muscle in rats is not well understood. It could be hypothesized that during the early postnatal period, i.e. when minimal weight-supporting activity occurs, the activity imposed by gravity would be of little consequence in directing the normal development of the skeletal musculature. We have addressed this issue by limiting the amount of postnatal weight-support activity of the hindlimbs of rats during the lactation period. We have focused on the development of three characteristics of the muscle fibers, i.e. size, myonuclear number and myosin heavy chain expression.
Document ID
20040087740
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Ohira, Y.
(Dept. Physiol. Biomech., NIFS, Kanoya, Japan)
Tanaka, T.
Yoshinaga, T.
Kawano, F.
Nomura, T.
Nonaka, I.
Allen, D. L.
Roy, R. R.
Edgerton, V. R.
Date Acquired
August 21, 2013
Publication Date
July 1, 2000
Publication Information
Publication: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume: 7
Issue: 2
ISSN: 1077-9248
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

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