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Effects of long-duration bed rest on structural compartments of m. soleus in manMagnetic resonance imaging (MRI), histomorphometry and electron microscopy of muscle demonstrate that long-term exposure to actual or simulated weightlessness (including head down bed rest) leads to decreased volume of antigravity muscles in mammals. In muscles interbundle space is occupied by the connective tissue. Rat studies show that hindlimb unloading induces muscle fiber atrophy along with increase in muscle non-fiber connective tissue compartment. Beside that, usually 20% of the muscle fiber volume is comprised by non-contractile (non-myofibrillar) compartment. The aim of the present study was to compare changes in muscle volume, and in muscle fiber size with alterations in myofibrillar apparatus, and in connective tissue compartment in human m. soleus under conditions of 120 day long head down bed rest (HDBR).
Document ID
Document Type
Reprint (Version printed in journal)
Belozerova, I. (State Scientific Center--Insitute for Biomedical Problems Moscow, Russia)
Shenkman, B.
Mazin, M.
Leblanc, A.
LeBlanc, A. D.
Date Acquired
August 21, 2013
Publication Date
July 1, 2001
Publication Information
Publication: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume: 8
Issue: 1
ISSN: 1077-9248
Subject Category
Aerospace Medicine
Distribution Limits
Non-NASA Center
NASA Discipline Musculoskeletal