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Behavioral consequences of radiation exposure to simulated space radiation in the C57BL/6 mouse: open field, rotorod, and acoustic startleTwo experiments were carried out to investigate the consequences of exposure to proton radiation, such as might occur for astronauts during space flight. C57BL/6 mice were exposed, either with or without 15-g/cm2 aluminum shielding, to 0-, 3-, or 4-Gy proton irradiation mimicking features of a solar particle event. Irradiation produced transient direct deficits in open-field exploratory behavior and acoustic startle habituation. Rotorod performance at 18 rpm was impaired by exposure to proton radiation and was impaired at 26 rpm, but only for mice irradiated with shielding and at the 4-Gy dose. Long-term (>2 weeks) indirect deficits in open-field activity appeared as a result of impaired experiential encoding immediately following exposure. A 2-week recovery prior to testing decreased most of the direct effects of exposure, with only rotorod performance at 26 rpm being impaired. These results suggest that the performance deficits may have been mediated by radiation damage to hippocampal, cerebellar, and possibly, forebrain dopaminergic function.
Document ID
20040087788
Document Type
Reprint (Version printed in journal)
Authors
Pecaut, Michael J. (Loma Linda University Loma Linda, California 92350, United States)
Haerich, Paul
Zuccarelli, Cara N.
Smith, Anna L.
Zendejas, Eric D.
Nelson, Gregory A.
Date Acquired
August 21, 2013
Publication Date
December 1, 2002
Publication Information
Publication: Cognitive, affective & behavioral neuroscience
Volume: 2
Issue: 4
ISSN: 1530-7026
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Radiation Health