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Regulatory coding of lymphoid lineage choice by hematopoietic transcription factorsDuring lymphopoiesis, precursor cells negotiate a complex regulatory space, defined by the levels of several competing and cross-regulating transcription factors, before arriving at stable states of commitment to the B-, T- and NK-specific developmental programs. Recent perturbation experiments provide evidence that this space has three major axes, corresponding to the PU.1 versus GATA-1 balance, the intensity of Notch signaling through the CSL pathway, and the ratio of E-box transcription factors to their Id protein antagonists.
Document ID
20040087794
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Warren, Luigi A.
(California Institute of Technology Pasadena, CA 91125, United States)
Rothenberg, Ellen V.
Date Acquired
August 21, 2013
Publication Date
April 1, 2003
Publication Information
Publication: Current opinion in immunology
Volume: 15
Issue: 2
ISSN: 0952-7915
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Evolutionary Biology
Review
NASA Program Fundamental Space Biology
Review, Tutorial

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