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Stressed to death: implication of lymphocyte apoptosis for psychoneuroimmunologyPsychological and physical stressors best exemplify the intercommunication of the immune and the nervous systems. It has been shown that stress significantly impacts leukocyte cellularity and immune responses and alters susceptibility to various diseases. While acute stress has been shown to enhance immune responses, chronic stress often leads to immunosuppression. Among many criteria examined upon exposure to chronic stress, the reduction in lymphocyte mitogenic response and lymphocyte cellularity are commonly assessed. We have reported that chronic restraint stress could induce lymphocyte reduction, an effect dependent on endogenous opioids. Interestingly, the effect of endogenous opioids was found to be exerted through increasing the expression of a cell death receptor, Fas, and an increased sensitivity of lymphocytes to apoptosis. Stress-induced lymphocyte reduction was not affected by adrenalectomy. In this review, based on available literature and our recent data, we will discuss the role of the hypothalamic-pituitary-adrenal axis and endogenous opioids and examine the mechanisms by which chronic stress modulates lymphocyte apoptosis.
Document ID
20040087812
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Shi, Yufang
(University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School 661 Hoes Lane, Piscataway 08854, United States)
Devadas, Satish
Greeneltch, Kristy M.
Yin, Deling
Allan Mufson, R.
Zhou, Jian-nian
Date Acquired
August 21, 2013
Publication Date
February 1, 2003
Publication Information
Publication: Brain, behavior, and immunity
Volume: 17 Suppl 1
ISSN: 0889-1591
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: AI43384
CONTRACT_GRANT: AI50222
Distribution Limits
Public
Copyright
Other
Keywords
Review Literature
Non-NASA Center
NASA Discipline Regulatory Physiology
Review

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