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Genetic control of Drosophila nerve cord developmentThe Drosophila ventral nerve cord has been a central model system for studying the molecular genetic mechanisms that control CNS development. Studies show that the generation of neural diversity is a multistep process initiated by the patterning and segmentation of the neuroectoderm. These events act together with the process of lateral inhibition to generate precursor cells (neuroblasts) with specific identities, distinguished by the expression of unique combinations of regulatory genes. The expression of these genes in a given neuroblast restricts the fate of its progeny, by activating specific combinations of downstream genes. These genes in turn specify the identity of any given postmitotic cell, which is evident by its cellular morphology and choice of neurotransmitter.
Document ID
20040087833
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Skeath, James B.
(Washington University School of Medicine 4566 Scott Avenue, St Louis, MO 63110, United States)
Thor, Stefan
Date Acquired
August 21, 2013
Publication Date
February 1, 2003
Publication Information
Publication: Current opinion in neurobiology
Volume: 13
Issue: 1
ISSN: 0959-4388
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review
Non-NASA Center
NASA Discipline Evolutionary Biology
Review, Tutorial

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