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Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acidsDebilitating injury is accompanied by hypercortisolemia, muscle wasting, and disruption of the normal anabolic response to food. We sought to determine whether acute hypercortisolemia alters muscle protein metabolism following ingestion of a potent anabolic stimulus: essential amino acids (EAA). A 27-h infusion (80 microg. kg(-1). h(-1)) of hydrocortisone sodium succinate mimicked cortisol (C) levels accompanying severe injury (>30 microg/dl), (C + AA; n = 6). The control group (AA) received intravenous saline (n = 6). Femoral arteriovenous blood samples and muscle biopsies were obtained during a primed (2.0 micromol/kg) constant infusion (0.05 micromol. kg(-1). min(-1)) of l-[ring-(2)H(5)]phenylalanine before and after ingestion of 15 g of EAA. Hypercortisolemia [36.5 +/- 2.1 (C + AA) vs. 9.0 +/- 1.0 microg/dl (AA)] increased postabsorptive arterial, venous, and muscle intracellular phenylalanine concentrations. Hypercortisolemia also increased postabsorptive and post-EAA insulin concentrations. Net protein balance was blunted (40% lower) following EAA ingestion but remained positive for a greater period of time (60 vs. 180 min) in the C + AA group. Thus, although differences in protein metabolism were evident, EAA ingestion improved muscle protein anabolism during acute hypercortisolemia and may help minimize muscle loss following debilitating injury.
Document ID
20040087866
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Paddon-Jones, Douglas
(Shriners Burns Hospital 815 Market Street, Galveston, TX 77550, United States)
Sheffield-Moore, Melinda
Creson, Daniel L.
Sanford, Arthur P.
Wolf, Steven E.
Wolfe, Robert R.
Ferrando, Arny A.
Date Acquired
August 21, 2013
Publication Date
May 1, 2003
Publication Information
Publication: American journal of physiology. Endocrinology and metabolism
Volume: 284
Issue: 5
ISSN: 0193-1849
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: M01 RR 00073
CONTRACT_GRANT: 5R01 GM 57295
Distribution Limits
Public
Copyright
Other
Keywords
Clinical Trial
Non-NASA Center
Randomized Controlled Trial
NASA Discipline Regulatory Physiology
NASA Discipline Musculoskeletal

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