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Development of the mouse vestibular system in the absence of gravity perceptionThe tilted mutant mouse, which lacks otoconia in the inner ear, was used to study development of the mouse vestibular system in the absence of gravity perception. Otoconia are dense particles composed of proteins and calcium carbonate crystals suspended in the gelatinous macular membrane. They enhance, and are largely responsible for, sensitivity to gravity. Morphometric analysis of the vestibular ganglion showed that the mutant developed more slowly than the normal controls, both in rate of development and cell number, particularly during the first week of post-natal development. The mutant ganglia also exhibited a reduction of cells during the first 6 days of post-natal development.
Document ID
Document Type
Reprint (Version printed in journal)
Smith, Michael (Brody School of Medicine, East Carolina University Greenville, NC 27858, United States)
Yuan Wang, Xiang
Wolgemuth, Debra J.
Murashov, Alexander K.
Date Acquired
August 21, 2013
Publication Date
January 10, 2003
Publication Information
Publication: Brain research. Developmental brain research
Volume: 140
Issue: 1
ISSN: 0165-3806
Subject Category
Life Sciences (General)
Distribution Limits
Non-NASA Center
NASA Discipline Developmental Biology