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The effects of spaceflight on adrenergic receptors and agonists and cell adhesion molecule expressionTwenty-two astronauts who flew aboard 10 different US Space Shuttle flights were studied 10 days before launch, on landing day, and 2-4 days post-landing. After landing, plasma levels of norepinephrine (p<0.01) were elevated. Lymphocyte beta(2)-adrenergic receptors were desensitized 2-4 days post-landing (p<0.02). The density of CD62L on lymphocytes was unchanged but the densities of CD11a (p<0.01) and CD54 (p<0.001) were down-regulated. CD11a density was also down-regulated on monocytes (p<0.01). Neutrophils showed an up-regulation of CD11a (p<0.01) and a down-regulation of CD54 (p<0.01). CD11a density on neutrophils remained up-regulated (p<0.01) and CD54 density remained down-regulated (p<0.01) at 2-4 days post-landing. Circulating levels of soluble ICAM-1 (CD54) and soluble E-selectin (CD62E) were decreased after landing (p's<0.05). The data suggest that spaceflight leads to an environment that would support reduced leukocyte-endothelial adhesion. Sympathetic activation may contribute to this phenomenon.
Document ID
20040088008
Acquisition Source
Johnson Space Center
Document Type
Reprint (Version printed in journal)
Authors
Mills, Paul J.
(University of California San Diego, La Jolla, CA 92103, United States)
Perez, Christy J.
Adler, Karen A.
Ziegler, Michael G.
Meck, J. V.
Date Acquired
August 21, 2013
Publication Date
November 1, 2002
Publication Information
Publication: Journal of neuroimmunology
Volume: 132
Issue: 2-Jan
ISSN: 0165-5728
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: HL57265
CONTRACT_GRANT: M01RR00827
Distribution Limits
Public
Copyright
Other
Keywords
Flight Experiment
manned
STS Shuttle Project
NASA Center JSC
NASA Discipline Cell Biology
short duration

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