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Autocrine and/or paracrine insulin-like growth factor-I activity in skeletal muscleSimilar to bone, skeletal muscle responds and adapts to changes in loading state via mechanisms that appear to be intrinsic to the muscle. One of the mechanisms modulating skeletal muscle adaptation it thought to involve the autocrine and/or paracrine production of insulinlike growth factor-I. This brief review outlines components of the insulinlike growth factor-I system as it relates to skeletal muscle and provides the rationale for the theory that insulinlike growth factor-I is involved with muscle adaptation.
Document ID
20040088022
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Adams, Gregory R.
(University of California-Irvine Irvine, CA 92697-4560, United States)
Date Acquired
August 21, 2013
Publication Date
October 1, 2002
Publication Information
Publication: Clinical orthopaedics and related research
Issue: 403 Suppl
ISSN: 0009-921X
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
NASA Discipline Musculoskeletal
Non-NASA Center
Review

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