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Lower body negative pressure as a tool for research in aerospace physiology and military medicineLower body negative pressure (LBNP) has been extensively used for decades in aerospace physiological research as a tool to investigate cardiovascular mechanisms that are associated with or underlie performance in aerospace and military environments. In comparison with clinical stand and tilt tests, LBNP represents a relatively safe methodology for inducing highly reproducible hemodynamic responses during exposure to footward fluid shifts similar to those experienced under orthostatic challenge. By maintaining an orthostatic challenge in a supine posture, removal of leg support (muscle pump) and head motion (vestibular stimuli) during LBNP provides the capability to isolate cardiovascular mechanisms that regulate blood pressure. LBNP can be used for physiological measurements, clinical diagnoses and investigational research comparisons of subject populations and alterations in physiological status. The applications of LBNP to the study of blood pressure regulation in spaceflight, groundbased simulations of low gravity, and hemorrhage have provided unique insights and understanding for development of countermeasures based on physiological mechanisms underlying the operational problems.
Document ID
Document Type
Reprint (Version printed in journal)
Convertino, V. A.
(U.S. Army Institute of Surgical Research Fort Sam Houston, TX 78234, United States)
Date Acquired
August 21, 2013
Publication Date
December 1, 2001
Publication Information
Publication: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume: 8
Issue: 2
ISSN: 1077-9248
Subject Category
Aerospace Medicine
Distribution Limits
Review, Tutorial
NASA Discipline Musculoskeletal
Non-NASA Center

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