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Integrated CMOS photodetectors and signal processing for very low-level chemical sensing with the bioluminescent bioreporter integrated circuitWe report an integrated CMOS microluminometer optimized for the detection of low-level bioluminescence as part of the bioluminescent bioreporter integrated circuit (BBIC). This microluminometer improves on previous devices through careful management of the sub-femtoampere currents, both signal and leakage, that flow in the front-end processing circuitry. In particular, the photodiode is operated with a reverse bias of only a few mV, requiring special attention to the reset circuitry of the current-to-frequency converter (CFC) that forms the front-end circuit. We report a sub-femtoampere leakage current and a minimum detectable signal (MDS) of 0.15 fA (1510 s integration time) using a room temperature 1.47 mm2 CMOS photodiode. This microluminometer can detect luminescence from as few as 5000 fully induced Pseudomonas fluorescens 5RL bacterial cells. c2002 Elsevier Science B.V. All rights reserved.
Document ID
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Bolton, Eric K.
(University of Tennessee Knoxville, TN 37916, United States)
Sayler, Gary S.
Nivens, David E.
Rochelle, James M.
Ripp, Steven
Simpson, Michael L.
Date Acquired
August 21, 2013
Publication Date
June 20, 2002
Publication Information
Publication: Sensors and actuators. B, Chemical
Volume: 85
Issue: 1-2
ISSN: 0925-4005
Subject Category
Life Sciences (General)
Distribution Limits
Non-NASA Center
NASA Discipline Life Sciences Technologies

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