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Growth and maturational changes in dense fibrous connective tissue following 14 days of rhGH supplementation in the dwarf ratThe purpose of this study was to investigate the impact of recombinant human growth hormone (rhGH) on patella tendon (PT), medial collateral ligament (MCL), and lateral collateral ligament (LCL) on collagen growth and maturational changes in dwarf GH-deficient rats. Twenty male Lewis mutant dwarf rats, 37 days of age, were randomly assigned to Dwarf + rhGH (n = 10) and Dwarf + vehicle (n = 10) groups. The GH group received 1.25 mg rhGH/kg body wt twice daily for 14 days. rhGH administration stimulated dense fibrous connective tissue growth, as demonstrated by significant increases in hydroxyproline specific activity and significant decreases in the non-reducible hydroxylysylpyridinoline (HP) collagen cross-link contents. The increase in the accumulation of newly accreted collagen was 114, 67, and 117% for PT, MCL, and LCL, respectively, in 72 h. These findings suggest that a short course rhGH treatment can affect the rate of new collagen production. However, the maturation of the tendon and ligament tissues decreased 18-25% during the rapid accumulation of de novo collagen. We conclude that acute rhGH administration in a dwarf rat can up-regulate new collagen accretion in dense fibrous connective tissues, while causing a reduction in collagen maturation. Copyright 2002 Elsevier Science Ltd.
Document ID
Document Type
Reprint (Version printed in journal)
Kyparos, Antonios
(University of Houston Houston, TX 77204-5001, United States)
Orth, Michael W.
Vailas, Arthur C.
Martinez, Daniel A.
Date Acquired
August 21, 2013
Publication Date
October 1, 2002
Publication Information
Publication: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Volume: 12
Issue: 5
ISSN: 1096-6374
Subject Category
Life Sciences (General)
Distribution Limits
NASA Discipline Musculoskeletal
Non-NASA Center
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