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Computational Model of the Modulation of Gene Expression Following DNA DamageHigh linear energy transfer (LET) radiation, such as heavy ions or neutrons, has an increased biological effectiveness compared to X rays for gene mutation, genomic instability, and carcinogenesis. In the traditional paradigm, mutations or chromosomal aberrations are causative of late effects. However, in recent years experimental evidence has demonstrated the important role of the description of the modification of gene expression by radiation in understanding the mechanisms of radiation action. In this report, approaches are discussed to the mathematical description of mRNA and protein expression kinetics following DNA damage. Several hypotheses for models of radiation modulation of protein expression are discussed including possible non-linear processes that evolve from the linear dose responses that follow the initial DNA damage produced by radiation.
Document ID
20040088154
Acquisition Source
Johnson Space Center
Document Type
Reprint (Version printed in journal)
Authors
Cucinotta, F. A.
(NASA Johnson Space Center Houston TX United States)
Dicello, J. F.
Nikjoo, H.
Cherubini, R.
Date Acquired
August 21, 2013
Publication Date
January 1, 2002
Publication Information
Publication: Radiation protection dosimetry
Volume: 99
Issue: 4-Jan
ISSN: 0144-8420
Subject Category
Life Sciences (General)
Report/Patent Number
JSC-CN-7139
Distribution Limits
Public
Copyright
Other
Keywords
NASA Center JSC
Non-NASA Center
NASA Discipline Radiation Health

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