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Record Details

Record 5 of 44383
Relative biological effectiveness of light ions in human tumoural cell lines: role of protein p53
Author and Affiliation:
Baggio, L.(INFN-Laboratori Nazionali di Legnaro, Legnaro-Padova, Italy)
Cavinato, M.
Cherubini, R.
Conzato, M.
Cucinotta, F.
Favaretto, S.
Gerardi, S.
Lora, S.
Stoppa, P.
Williams, J. R.
Abstract: Protons and alpha particles of high linear energy transfer (LET) have shown an increased relative biological effectiveness (RBE) with respect to X/gamma rays for several cellular and molecular endpoints in different in vitro cell systems. To contribute to understanding the biochemical mechanisms involved in the increased effectiveness of high LET radiation, an extensive study has been designed. The present work reports the preliminary result of this study on two human tumoural cell lines, DLD1 and HCT116, (with different p53 status), which indicate that for these cell lines, p53 does not appear to take a part in the response to radiation induced DNA damage, suggesting an alternative p53-independent pathway and a cell biochemical mechanism dependent on the cell type.
Publication Date: Jan 01, 2002
Document ID:
20040088155
(Acquired Sep 07, 2004)
Subject Category: BEHAVIORAL SCIENCES
Document Type: Journal Article
Publication Information: Radiation protection dosimetry (ISSN 0144-8420); Volume 99; 1-4; 211-4
Publisher Information: United Kingdom
Financial Sponsor: NASA Johnson Space Center; Houston TX United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ALPHA PARTICLES; BIOLOGICAL EFFECTS; CELLS (BIOLOGY); HUMAN PERFORMANCE; LIGHT (VISIBLE RADIATION); LIGHT IONS; PROTEINS; PROTONS; SURVIVAL; TUMOR SUPPRESSOR PROTEINS; CULTURED CELLS; GENE EXPRESSION REGULATION; GENETICS; NEOPLASMS; RADIATION EFFECTS; TUMORS
Other Descriptors: ALPHA PARTICLES; CELL SURVIVAL/RADIATION EFFECTS; LIGHT; PROTEIN P53/GENETICS/RADIATION EFFECTS; PROTONS; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS/PATHOLOGY; GENE EXPRESSION REGULATION, NEOPLASTIC/RADIATION EFFECTS; HUMAN; TUMOR CELLS, CULTURED; NASA CENTER JSC; NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER
Availability Source: Other Sources
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