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Stimulus and recording variables and their effects on mammalian vestibular evoked potentialsLinear vestibular evoked potentials (VsEPs) measure the collective neural activity of the gravity receptor organs in the inner ear that respond to linear acceleration transients. The present study examined the effects of electrode placement, analog filtering, stimulus polarity and stimulus rate on linear VsEP thresholds, latencies and amplitudes recorded from mice. Two electrode-recording montages were evaluated, rostral (forebrain) to 'mastoid' and caudal (cerebellum) to 'mastoid'. VsEP thresholds and peak latencies were identical between the two recording sites; however, peak amplitudes were larger for the caudal recording montage. VsEPs were also affected by filtering. Results suggest optimum high pass filter cutoff at 100-300 Hz, and low pass filter cutoff at 10,000 Hz. To evaluate stimulus rate, linear jerk pulses were presented at 9.2, 16, 25, 40 and 80 Hz. At 80 Hz, mean latencies were longer (0.350-0.450 ms) and mean amplitudes reduced (0.8-1.8 microV) for all response peaks. In 50% of animals, late peaks (P3, N3) disappeared at 80 Hz. The results offer options for VsEP recording protocols. Copyright 2002 Elsevier Science B.V.
Document ID
20040088168
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Jones, Sherri M.
(University of Missouri School of Medicine Rm 205 Allton Bldg., DC375.00, 301 Business Loop 70W, Columbia, MO 65212, United States)
Subramanian, Geetha
Avniel, Wilma
Guo, Yuqing
Burkard, Robert F.
Jones, Timothy A.
Date Acquired
August 21, 2013
Publication Date
July 30, 2002
Publication Information
Publication: Journal of neuroscience methods
Volume: 118
Issue: 1
ISSN: 0165-0270
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: R01 DC04477
CONTRACT_GRANT: AG09524
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Neuroscience

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