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Epstein-Barr virus and human immunodeficiency virus serological responses and viral burdens in HIV-infected patients treated with HAARTEpstein-Barr virus (EBV) associated non-Hodgkin lymphoma is recognized as a complication of human immunodeficiency virus (HIV) infection. Little is known regarding the influence of highly active antiretroviral therapy (HAART) on the biology of EBV in this population. To characterize the EBV- and HIV-specific serological responses together with EBV DNA levels in a cohort of HIV-infected adults treated with HAART, a study was conducted to compare EBV and HIV serologies and EBV DNA copy number (DNAemia) over a 12-month period after the commencement of HAART. All patients were seropositive for EBV at baseline. Approximately 50% of patients had detectable EBV DNA at baseline, and 27/30 had detectable EBV DNA at some point over the follow-up period of 1 year. Changes in EBV DNA copy number over time for any individual were unpredictable. Significant increases in the levels of Epstein-Barr nuclear antigen (EBNA) and Epstein-Barr early antigen (EA) antibodies were demonstrated in the 17 patients who had a good response to HAART. Of 29 patients with paired samples tested, four-fold or greater increases in titers were detected for EA in 12/29 (41%), for EBNA in 7/29 (24%), for VCA-IgG in 4/29 (14%); four-fold decreases in titers were detected in 2/29 (7%) for EA and 12/29 (41%) for EBNA. A significant decline in the titer of anti-HIV antibodies was also demonstrated. It was concluded that patients with advanced HIV infection who respond to HAART have an increase in their EBV specific antibodies and a decrease in their HIV-specific antibodies. For the cohort overall, there was a transient increase in EBV DNA levels that had declined by 12 months. Copyright 2002 Wiley-Liss, Inc.
Document ID
20040088230
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
O'Sullivan, Cathal E. (University of Alabama at Birmingham Birmingham, Alabama, United States)
Peng, RongSheng
Cole, Kelly Stefano
Montelaro, Ronald C.
Sturgeon, Timothy
Jenson, Hal B.
Ling, Paul D.
Butel, J. S.
Date Acquired
August 21, 2013
Publication Date
July 1, 2002
Publication Information
Publication: Journal of medical virology
Volume: 67
Issue: 3
ISSN: 0146-6615
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: AI28243
CONTRACT_GRANT: AI-27767
CONTRACT_GRANT: AI36211
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
Non-NASA Center